Fluctuaciones de presión intraocular en pacientes operados con implante de implantable collamer lens (ICL V4c). Seguimiento a 3 meses / Intraocular pressure fluctuations in patients implanted with an implantable collamer lens (ICL V4c). Three-month follow-up

Introducción: Una de las complicaciones del implante de ICL es la elevación de la presión intraocular (PIO), la cual es fluctuante y su alteración es un factor predictivo para el desarrollo de glaucoma. Material y métodos: Estudio prospectivo, transversal y analítico, en pacientes candidatos a implante de ICL. Previa valoración clínica completa, biometría y curva de PIO nocturna, posición supina, con 4 tomas, determinando la fluctuación, considerándose anormal por encima de 5 mmHg. Se les sometió a cirugía mediante técnica convencional. A los 3 meses se repitió valoración clínica completa, biometría y curva de PIO, para determinar si había cambios en las fluctuaciones de PIO. Resultados: Se estudiaron 31 ojos de 16 pacientes. El promedio de fluctuación preoperatorio fue de 3,35 ± 2 mmHg, mientras en el postoperatorio fue de 3,0 ± 2,2 mmHg, sin que esta diferencia fuera estadísticamente significativa. La agudeza, capacidad visual y equivalente esférico mostraron una mejoría estadísticamente significativa. Hubo 6 casos con complicaciones, las cuales se relacionaron con un vault alto y un ICL de mayor tamaño. No hubo relación entre estos hallazgos con el grado del ángulo camerular, el grado de pigmento o el nivel de entrenamiento del cirujano. Conclusión: Se exploró por primera vez el efecto del implante de ICL en las fluctuaciones de PIO, encontrando que no es estadísticamente significativo. Se mostró la seguridad y reproducibilidad del procedimiento, como en publicaciones previas, agregando que el nivel de entrenamiento del cirujano no es un factor determinante en estos hallazgos

Introduction: Fluctuating elevated intraocular pressure (IOP) is one of the complications of an implantable collamer lens (ICL), and its alteration is a predictive factor for the development of glaucoma. Material and methods: A prospective, cross-sectional analytic study was conducted on patients suitable for ICL implantation. Complete clinical and biometric work-ups were performed, as well as night-time IOP curve, in supine position, with 4 determinations, in order to assess fluctuation, considering abnormal with a value higher than 5 mmHg. Patients underwent surgery with conventional technique and three months after the work-ups were repeated, including a night-time IOP curve to assess any changes in IOP fluctuations. Results: A total of 31 eyes of 16 patients were studied. Mean IOP fluctuation in the preoperative assessment was 3.35 ± 2 mmHg, whereas the postoperative mean was 3.0 ± 2.2 mmHg, with the difference not being statistically significant. Visual acuity and capacity, as well as spheric equivalent did show a statistically significant improvement. There were 6 cases of complications, which were related to a higher vault and a greater ICL size. There was no relationship between these findings and the angle grade, pigment, and the level of training of the surgeon. Conclusions: The effect of an ICL on IOP fluctuations, has been studied for the first time, which was found to be not statistically significant. As in previous publications, the procedure was safe and reproducible, adding the fact that the level of training of the surgeon is not a determining factor in these findings

Intraocular pressure fluctuations in patients implanted with an implantable collamer lens (ICL V4c). Three-month follow-up. / Fluctuaciones de presión intraocular en pacientes operados con implante de implantable collamer lens (ICL V4c). Seguimiento a 3 meses.

INTRODUCTION: Fluctuating elevated intraocular pressure (IOP) is one of the complications of an implantable collamer lens (ICL), and its alteration is a predictive factor for the development of glaucoma. MATERIAL AND METHODS: A prospective, cross-sectional analytic study was conducted on patients suitable for ICL implantation. Complete clinical and biometric work-ups were performed, as well as night-time IOP curve, in supine position, with 4 determinations, in order to assess fluctuation, considering abnormal with a value higher than 5 mmHg. Patients underwent surgery with conventional technique and three months after the work-ups were repeated, including a night-time IOP curve to assess any changes in IOP fluctuations. RESULTS: A total of 31 eyes of 16 patients were studied. Mean IOP fluctuation in the preoperative assessment was 3.35 ± 2 mmHg, whereas the postoperative mean was 3.0 ± 2.2 mmHg, with the difference not being statistically significant. Visual acuity and capacity, as well as spheric equivalent did show a statistically significant improvement. There were 6 cases of complications, which were related to a higher vault and a greater ICL size. There was no relationship between these findings and the angle grade, pigment, and the level of training of the surgeon. CONCLUSIONS: The effect of an ICL on IOP fluctuations, has been studied for the first time, which was found to be not statistically significant. As in previous publications, the procedure was safe and reproducible, adding the fact that the level of training of the surgeon is not a determining factor in these findings.

Estudio comparativo de la seguridad y eficacia entre el dispositivo valvular de Ahmed modelo M4 (polietileno poroso de alta densidad) y el modelo S2 (polipropileno) en pacientes con diagnóstico de glaucoma neovascular / Comparative study of the safety and efficacy of the Ahmed glaucoma valve model M4 (high density porous polyethylene) and the model S2 (polypropylene) in patients with neovascular glaucoma

OBJETIVO: El objetivo de este estudio fue evaluar de forma prospectiva la seguridad y eficacia del dispositivo valvulado de Ahmed modelo M4 (sistema valvular convencional en plato de polietileno poroso de alta densidad, Medpor) comparado con el modelo S2 (plato de polipropileno). MÉTODO: Se formaron 2 grupos de pacientes con glaucoma neovascular. Un grupo en el que se implantó el dispositivo M4 y el grupo en el que se implantó el dispositivo S2. En ambos grupos (M4 y S2) se incluyó a pacientes mestizos mexicanos. Dichos pacientes fueron intervenidos quirúrgicamente, utilizando la técnica convencional consistente en la fijación escleral del cuerpo valvular en el cuadrante temporal superior a 8mm del limbo y realizando un túnel subepiescleral para colocar el tubo del dispositivo dentro de la cámara anterior, de acuerdo con la técnica descrita por nuestro grupo en forma previa. Después de un año de seguimiento los resultados fueron evaluados tomando en cuenta la reducción de la presión intraocular (PIO), los cambios en la agudeza visual, el uso de hipotensores oculares complementarios y las complicaciones aparecidas, así como las características demográficas de cada grupo. En el caso del modelo M4, los procedimientos quirúrgicos fueron realizados por el mismo cirujano (FGC). Los pacientes en los que se implantó el modelo S2 fueron operados por diversos cirujanos, incluyendo a FGC, del Servicio de Glaucoma del Hospital Dr. Luis Sánchez Bulnes de la Asociación para Evitar la Ceguera en México (APEC). RESULTADOS: En cada uno de los 2 grupos se operaron 21 ojos de 21 pacientes con diagnóstico de glaucoma neovascular, conformando los 42 ojos incluidos en este estudio. La PIO promedio en el preoperatorio fue de 43,5mmHg (±11,8) para el grupo de M4 y de 42,24mmHg (±12,84) para el grupo de S2. Después de un año de seguimiento, la PIO reportada fue 18,9mmHg (±9,7) para el grupo de M4 y 16,38mmHg (±9,76) para el grupo de S2. CONCLUSIONES: Creemos que es necesario efectuar un mayor número de estudios a largo plazo con un número mayor de pacientes, para poder evaluar la ayuda de esta cubierta porosa en el control tensional de los pacientes con el diagnóstico de GNV

OBJECTIVE: To prospectively evaluate the safety and efficacy of the Ahmed glaucoma valve model M4 (High density porous polyethylene plate; Medpor) compared with the model S2 (polypropylene plate). METHOD: Mexican patients with neovascular glaucoma were randomly included for each group (M4 and S2). They were operated on using conventional techniques and creating a sub-episcleral tunnel to place the valve tube in the anterior chamber. After one year of follow-up, the results were evaluated with respect to a post-operative reduction in pressure, changes in visual acuity, the need for drugs, and complications, as well as the demographic characteristics of each group. Each operation using the M4 valve was performed by a single surgeon (FGC). Those operated on using the S2 model had their surgery performed by the staff surgeons at the Glaucoma Department of the Mexican Association to Prevent Blindness (APEC). RESULTS: Each group (M4 and S2) contained 21 eyes of 21 Mexican patients with a diagnosis of neovascular glaucoma, leading to a total of 42 patients undergoing surgery. The mean preoperative intraocular pressure (IOP) was 43.5 (±11.8), and 42.24 (±12.84) mmHg for the M4 and S2 groups, respectively. After one year of follow-up, the IOP reported was 18.9 (±9.7) mmHg for the final 18 patients in the M4 group, and 16.38 (±9.76) mmHg for the 21 patients in the S2 group. DISCUSSION: The design of a drainage valve device such as that of Ahmed has characteristics such as moderate control of IOP, thanks to the valve component in the immediate post-operative period, which makes them safer than other non-valve devices. This avoids an excess of flat chambers and the presence of low IOPs, which can lead to bleeding in the early post-operative period due to the weak desmosomal junctions of the newly formed vessels, with the advantage of maintaining suitable control of IOP from the first day after surgery. CONCLUSION: Further studies with longer follow-up with a larger number of patients are needed to evaluate the effectiveness of this porous coating in the control of neovascular glaucoma

Comparative study of the safety and efficacy of the Ahmed glaucoma valve model M4 (high density porous polyethylene) and the model S2 (polypropylene) in patients with neovascular glaucoma. / Estudio comparativo de la seguridad y eficacia entre el dispositivo valvular de Ahmed modelo M4 (polietileno poroso de alta densidad) y el modelo S2 (polipropileno) en pacientes con diagnóstico de glaucoma neovascular.

OBJECTIVE: To prospectively evaluate the safety and efficacy of the Ahmed glaucoma valve model M4 (High density porous polyethylene plate; Medpor) compared with the model S2 (polypropylene plate). METHOD: Mexican patients with neovascular glaucoma were randomly included for each group (M4 and S2). They were operated on using conventional techniques and creating a sub-episcleral tunnel to place the valve tube in the anterior chamber. After one year of follow-up, the results were evaluated with respect to a post-operative reduction in pressure, changes in visual acuity, the need for drugs, and complications, as well as the demographic characteristics of each group. Each operation using the M4 valve was performed by a single surgeon (FGC). Those operated on using the S2 model had their surgery performed by the staff surgeons at the Glaucoma Department of the Mexican Association to Prevent Blindness (APEC). RESULTS: Each group (M4 and S2) contained 21 eyes of 21 Mexican patients with a diagnosis of neovascular glaucoma, leading to a total of 42 patients undergoing surgery. The mean preoperative intraocular pressure (IOP) was 43.5 (±11.8), and 42.24 (±12.84) mmHg for the M4 and S2 groups, respectively. After one year of follow-up, the IOP reported was 18.9 (±9.7) mmHg for the final 18 patients in the M4 group, and 16.38 (±9.76) mmHg for the 21 patients in the S2 group. DISCUSSION: The design of a drainage valve device such as that of Ahmed has characteristics such as moderate control of IOP, thanks to the valve component in the immediate post-operative period, which makes them safer than other non-valve devices. This avoids an excess of flat chambers and the presence of low IOPs, which can lead to bleeding in the early post-operative period due to the weak desmosomal junctions of the newly formed vessels, with the advantage of maintaining suitable control of IOP from the first day after surgery. CONCLUSION: Further studies with longer follow-up with a larger number of patients are needed to evaluate the effectiveness of this porous coating in the control of neovascular glaucoma.

Switching prostaglandin analogues and 24-hour IOP fluctuations.

OBJECTIVES: To evaluate the fluctuations in 24h mean intraocular pressure (IOP) when switching prostaglandin analogues in patients with glaucoma. METHODS: Fourteen patients with primary open angle glaucoma were evaluated with monthly 24-hour IOP curves, using a monthly switching pattern of prostaglandin analogues and brinzolamide during 3 years of follow-up. RESULTS: Average IOP and average fluctuation (peak to through difference) were significantly higher with brinzolamide than with any of the analogues. There was no significant difference in either parameter with the different prostaglandin analogues, regardless of the order in which they were evaluated, or even if a month on brinzolamide was intercalated between the analogues. CONCLUSIONS: Brinzolamide was less effective than prostaglandin analogues in reducing 24-hour mean IOP and its fluctuations. Switching analogues had no significant effect on mean IOP or mean IOP fluctuations.

Rotación de análogos de prostaglandinas y fluctuaciones diurnas de la presión intraocular / Switching prostaglandin analogues and 24-hour iop fluctuations

Objetivos: Evaluar la eficacia de la rotación de análogos de prostaglandinas sobre las fluctuaciones de la presión intraocular (PIO) en 24h. Métodos: Se evaluó a 14 pacientes con glaucoma primario de ángulo abierto mediante curvas mensuales de presión intraocular de 24h, realizando un patrón de cambios mensuales del tratamiento hipotensor entre brinzolamida y análogos de prostaglandinas durante un período de tres años. Resultados: Tanto el promedio de PIO como el promedio de variación (diferencia entre el pico y el valle) durante las curvas fueron significativamente mayores con la brinzolamida que con cualquiera de los tres análogos. Tanto el promedio de PIO como el promedio de fluctuaciones fueron similares entre los tres análogos, independiente del orden en que se usaron o de si se intercaló un mes de brinzolamida entre uno y otro análogo. Conclusiones: La brinzolamida fue menos efectiva para reducir la PIO promedio y sus fluctuaciones durante 24h. No hubo un cambio significativo al rotar los análogos(AU)

Objectives: To evaluate the fluctuations in 24h mean intraocular pressure (IOP) when switching prostaglandin analogues in patients with glaucoma. Methods: Fourteen patients with primary open angle glaucoma were evaluated with monthly 24-hour IOP curves, using a monthly switching pattern of prostaglandin analogues and brinzolamide during 3 years of follow-up. Results: Average IOP and average fluctuation (peak to through difference) were significantly higher with brinzolamide than with any of the analogues. There was no significant difference in either parameter with the different prostaglandin analogues, regardless of the order in which they were evaluated, or even if a month on brinzolamide was intercalated between the analogues. Conclusions: Brinzolamide was less effective than prostaglandin analogues in reducing 24-hour mean IOP and its fluctuations. Switching analogues had no significant effect on mean IOP or mean IOP fluctuations(AU)